Mark A. Lyle, PT, PhD

Assistant Professor

Department of Rehabilitation Medicine


  • Postdoctoral Fellowship, Georgia Institute of Technology, 2017
  • PhD, University of Southern California, 2012
  • MS, Simmons College, 2002
  • BA, Miami University, 1998


The overall goal of my research is to enhance mobility and improve quality of life for patients with locomotor impairments across the lifespan, and identify modifiable factors that will enable effective strategies to prevent injury.

Our research focus over the last 10 years has been to identify governing neural control principles that enable normal and underlie impaired task dependent lower limb control with an emphasis on clarifying the functional role of proprioceptive feedback (i.e. muscle spindles and Golgi tendon organs). Proprioceptive feedback is known to have a role in coordinating muscle activity throughout the limb, and this is achieved by muscles continuously “talking to each other” via proprioceptive networks. Our lab is particularly interested in determining how and to what extent proprioceptive feedback is modulated to meet unique task demands, and the extent to which the adaptive capacity to modulate proprioceptive feedback is influenced by injuries, aging and rehabilitation strategies (e.g. motor practice, targeted neuromodulation). Our efforts aim to improve the clinical management of locomotor deficits and falls in older adults, impaired mobility in patients with neurological and musculoskeletal conditions and injury prevention strategies in athletes. Relying on the fields of biomechanics, neuroscience and muscle physiology, we use technology such as 3D motion analysis, electromyography, muscle/nerve stimulation paradigms, and strength and functional assessments.

Awards and Honors

  • 2007  Promotion of Doctoral Studies I, Foundation for Physical Therapy
  • 2008  Promotion of Doctoral Studies I, Foundation for Physical Therapy
  • 2010  Promotion of Doctoral Studies II, Foundation for Physical Therapy
  • 2011  Biokinesiology Graduate Research Poster Award, Univ. of Southern California
  • 2011  Outstanding Mentorship Award, Univ. of Southern California
  • 2011  The University Outstanding Teaching Assistant Award, Univ. of Southern California
  • 2012  Marilyn Gossman Student Research Award, American Physical Therapy Association
  • 2012  Order of the Golden Cane Outstanding Achievement Award, Univ. of Southern California
  • 2013 – 2016  NRSA F32 Postdoctoral Fellowship, NINDS
  • 2014  Mentee, Training in Grantsmanship for Rehabilitation Research, NIH/NICHD T15HD074546


  • Lyle MA, Nichols TR. Patterns of intermuscular inhibitory force feedback across cat hindlimbs suggest a flexible system for regulating whole limb mechanics. Journal of Neurophysiology. 2017, DOI: 10.1152/jn.00617.2017
  • Lyle MA, Nichols TR, Kajtaz E, Maas H. Musculotendon adaptations and preservation of spinal reflex pathways following agonist-to-antagonist tendon transfer, Physiological Reports, 2017; 5(9), no. e13201.
  • Lyle MA, Prilutsky BI, Gregor RJ, Abelew T, Nichols TR. Self-reinnervated muscles lose autogenic length feedback but intermuscular feedback can recover functional connectivity. Journal of Neurophysiology. 2016, 116(3):1055-67.
  • Nichols TR, Bunderson NE, Lyle MA. Neural regulation of limb mechanics: Insights from the organization of proprioceptive circuits. In Neuromechanical Modeling of Posture and Locomotion. Prilutsky BI, Edwards DH (Editors). Springer, New York, NY, 2016, pp. 69-102.
  • Lyle MA, Valero-Cuevas FJ, Gregor RJ, Powers CM. Lower extremity dexterity is associated with change of direction ability in high school soccer athletes. Scandinavian Journal of Medicine & Science in Sports. 2015, 25(1):81-8.
  • Gregor RJ, Childers WL, Lyle MA, Fetters L. Interdisciplinary-Integration-Interface: The Past, Present, and Future of Biomechanics. Kinesiology Review. 2014, 3:19-37.
  • Lyle MA, Valero-Cuevas FJ, Gregor RJ, Powers CM. Control of dynamic foot-ground interactions in male and female soccer athletes: lower limb dexterity and limb stiffness during landing. Journal of Biomechanics.2014, 47(2):512-7.
  • Lyle MA, Valero-Cuevas FJ, Gregor RJ, Powers CM. The lower extremity dexterity test as a measure of lower extremity dynamical capability. Journal of Biomechanics. 2013, 46(5): 998-1002.
  • Khayambash K, Mohammadkhan Z, Ghaznavi K, Lyle MA, Powers CM. The effects of isolated hip abductor and external rotator muscle strengthening on pain and health status in females with patellofemoral pain. Journal of Orthopedic and Sports Physical Therapy. 2012, 42(1):22-29.
  • Lyle MA, Sigward SM, Tsai L-C, Pollard CD, Powers CM. Influence of maturation on instep kick biomechanics in female soccer athletes. Medicine and Science in Sports and Exercise. 2011, 43(10):1948-54.
  • Lyle MA, Manes S, McGuinness M, Ziaei S, Iversen MD. Relationship of physical examination findings and self-reported symptom severity and function in patients with degenerative lumbar conditions. Physical Therapy. 2005, 85(2):120-133.